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A Cochrane review examining chromium supplementation noted that evidence quality varied significantly across studies

Conventionally, thresholds for low, moderate, and substantial heterogeneity are established as I 2 values of 25%, 50%, and 75%, respectively [23]

and V.A

50 Based on the review of these 3 RCTs, in addition to the review of another 84 manuscripts of smaller studies, the American Society of Clinical Oncology discourages the use of ALC amongst cancer patients, due to concerns of the risks outweighing the benefits

Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis